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Blood Cancer Journal

Submitted by nkantorovich on Fri, 09/20/2019 - 13:00

 

Plasma cell dyscrasias is discussed in this article through the analysis of multiple myeloma. Multiple myeloma is a cancer of the plasma cells but of a certain type. When plasma cells begin to grow abnormally, they make a certain type of antibody and form a monoclonal paraprotein. They can be detected in the bone marrow and other tissues. The premalignant stage of multiple myeloma is characterized by the presence of the abnormal antibody, monoclonal gammopathy of undetermined significance (MGUS). This antibody is present in 3-4% of normal individuals over the age of 50 years old and is only an issue if it progresses to multiple myeloma. The risk of MGUS progression to multiple myeloma increases by 10% in the first 5 years after diagnosis MGUS could also develop into a different plasma cell disorder as it is still an abnormal protein. This development could lead to disorders such as plasma cell leukemia or Waldenstrom macroglobulinemia. 

 
Jelinek, T, et al. “Current Applications of Multiparameter Flow Cytometry in Plasma Cell Disorders.” Nature News, Nature Publishing Group, 20 Oct. 2017, www.nature.com/articles/bcj201790.
 

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Comments

In the first sentence you could state the name of the article rather than saying "in this aticle" I didnt know what article you were refering too until I got the end of the paragraph and saw the citation.

'Multiple myeloma is a cancer of the plasma cells but of a certain type. When plasma cells begin to grow abnormally, they make a certain type of antibody and form a monoclonal paraprotein.' can be reworded to 'Abnormal plasma cell growth causes antibody and monoclonal paraproteins to build up in the body which leads to a disease known as multiple myeloma.' This way you can avoid wordiness like 'but of a certain type' while carrying the same meaning.

I think you should have a better concluding last sentence. You finished with ; This development could lead to disorders such as plasma cell leukemia or Waldenstrom macroglobulinemia. I think perhaps you can keep going on the idea and what any possible questions you may have.