Ibuprofen

Ibuprofen inhibits prostaglandin formation. Prostaglandin dilates afferent arterioles. Since ibuprofen inhibits prostaglandin, our afferent arteriole can no longer be as dilated as it was before, which will decrease blood flow in the kidney and therefore filtration. When we exercise, we constrict vessels in the kidney and slow down blood flow in order to focus more on the muscles we are using when we exercise. We would definitely not want to take ibuprofen while exercising, as this would stress our kidney out even more and would cause more constriction and reduced blood flow to the arterioles supplying blood for the kidney.