Neurobio

This was also conducted on male mouse which show body weight fluctuations less obviously than women. The results of the study could have shown different results if it was done with female mice. Energy is very important for the function of our body, especially the brain. For example, if there is not enough glucose then action potentials cannot fire. Now what happens if you have an excess of energy, we would want to activate aMSH. If we are in the opposite situation, we would want to inhibit AgRP. Leptin is expressed in proportion to the amount of fat that you have. It has the ability to activitate aMSH or inhibit AgRP. ob/ob mutants are not able to activate the aMSH but also not inhibit the AgRP. Now lets say this was done to a Pomc neuron. This would cause the Pomc neuron to die and now the aMish neuron would not turn off satiety. Therefore they would never feel satiated. There was an increase in the amount that they ate but their phenotype in body weight changed much more slowly.