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summary of methods from a study on LDL

Submitted by ziweiwang on Thu, 09/19/2019 - 22:55

In the study with the LDL, 25 patients with high blood LDL, was gathered. The 20 of patients had high blood cholesterol, but none of the patients were likely to have FH.  Five patients with heterozygous FH has gathered apart from the 20 patients. The participants with heterozygous were determined by their high LDL blood level in the blood which was much higher than the patients. The 20 participants were given two types of labeled LDL. The first type of LDL that was used is the patient's own LDL, which was extracted by their blood, labeled and inserted back into the body. The other type of LDL was obtained from first-year medical students who had normal blood cholesterol levels and fit the criteria for giving blood. The patients were then all admitted to the hospital for the study and were given a relatively high-fat diet.  The LDL turn over was studie by taking blood from taken from the donors and removed and the amount of the two labeled LDL was detected. 

The result of the study is that while in patients with Het FH, neither LDL was absorbed well. In some of the 20 patients who did not have FH, the patients had a much higher turnover rate of medical student's LDL compared to their own LDL. This indicates that the patient's own LDL is not structurally compatible with the LDL receptors in the cell, and indicate that the patients were unable to make normal LDL. since the absorption of the LDL in the blood causes the cells to decrease the production of LDL, it is not unreasonable to say that the unusual structure of the LDL protein is the cause of high cholesterol in these patients. If that was a true one of the ways that it can be treated is to inject LDL from someone else in to their blood. However, this treatment is not cost-effective, since the patients who have a misformed LDL inly have a slightly higher pressure than normal.