Neurobio

If you administered hDTR, known as deferiotoxin, to a mouse they would not respond. This is because the mouse is not responsive to human virus. The best way to get the virus into the mouse, would to package it into a virus shell and inject it into the mouse. The result from this injection would be the expression of Agrp, which would become infected with this toxin. For some background, Agrp inhibit the MCAR which shuts down the satiety neuron, which drives hunger. The phenotype of this injection would be lead for the receptor The hDTR would not connect to Agrp neurons and cause them to go through apoptosis. This would lead to a decrease in body weight. AgRP shuts off satiety neuron, which tells you that you’re full. This causes the mouse to stop eating and die of starvation. They feel satiented the whole time as there is not a receptor to shut it off. Within five days their food intake drops to 20% of the amount that they initially consumed.