Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. One of these hormones, prostaglandin, is inhibited when taking the medication. The synthesis of prostaglandin results in dilation of afferent arterioles. Because ibuprofen inhibits the formation of prostaglandin, our afferent arteriole’s begin to constrict without a signal to dilate due to the absence of the hormone. As a result, there is a decrease of blood flow in the kidney and therefore filtration is also reduced.
When we exercise, our vessels constrict in the kidney and slow down blood flow so that our bodies can focus more pumping blood to the muscles as we are using them when we exercise. From the information just learned, taking ibuprofen for a cramp during physical exercise would only have negative effects on the body. This would increase stress on the kidney inducing further constriction and reduced blood flow to the arterioles.