There are a few hormones involved in the regulation of digestion, but we’re only going to talk about a few of them. Gastrin stimulates the stomach and the small intestine. Histamine is another hormone, stimulates HCl production in the stomach (to acidify the contents). Secretin is a hormone that inhibits the stomach while also stimulating the small intestine. Cholecystokinin stimulates the small intestine and digestion but inhibits stomach. Secretin and cholecystokinin are active during the intestinal phase of digestion (they’re stimulating the small intestine and not the stomach). Undigested food enters the duodenum and inhibits gastric emptying in the Intestinal phase. The distension from the gastric phase leads to gastrin release in the blood. Secretin and cholecystokinin inhibit stomach activity until contents are digested.
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