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Draft 40

Submitted by dfmiller on Thu, 11/21/2019 - 20:49

Weatherbee, S. D., Behringer, R. R., Rasweiler, J. J., & Niswander, L. A. (2006). Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification. Proceedings of the National Academy of Sciences, 103(41), 15103–15107. doi: 10.1073/pnas.0604934103

  • Discusses the process of interdigital webbing in mammals, including examples of bat forelimb webbing retention and duck hindlimb webbing retention. Inhibition of apoptosis caused by Gre and FGF signaling within interdigital space results in retention of membrane.

Pajni-Underwood, S., Wilson, C. P., Elder, C., Mishina, Y., & Lewandoski, M. (2007). BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development, 134(12), 2359–2368. doi: 10.1242/dev.001677

  • Discusses BMPs used as a regulator of programmed cell death within the interdigital membrane. Bmpr1a inactivation in mice after limb bud initiation results in upregulation of Fgf4 and Fgf8. Inactivation of Bmpr1a also results in decreased apoptosis within interdigital membrane, leading to webbed digits.