Alzheimer's disease is a very impactful disease that has been extensively researched because of its dramatic effects on those with it and its high virulancy. Even then, research is ongoing and continuously discovering more. The beta amyloid accumulation in neurons of alzheimers patients shows to cause neurological dysfunctions that may be attributed to the disease, although the symptoms may also be due to mitochondrial errors. the function of the mitochondria relies heavily on its interactions with other organelles in the cell. Mitochondria–ER contacts are used for mitochondria and ER to share membrane bound proteins. An experiment with dysfunctional amyloid betas was done and it found swelling in the eR and mitochondria issues in the test subjects. This mechanism could be driving some of the Alzheimer's symptoms from over accumulation or not working amyloids.
A potential role for mitochondria–ER contacts in the pathology of Alzheimer's disease
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