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Glucose sensing neurons are far from a new discovery, they have actually been known for around 50 years. However, their physiological function has yet to be understood clearly. In a recent study, Oh et al. discovered the mechanism of glucose sensing these cells perform. Oh et al. identified a pair of neurons with bifurcated axons. One of these axons signaled to insulin producing cells to trigger the release of Drosophila Insulin-like peptide 2 (DILP2)¹. The other signals to adipokinetic hormone (AKH), a fly equivalent to glucagon, producing cells to trigger its release¹. Oh et al. then proposed that this mechanism is used for glucose homeostasis in Drosophila.