Professor Seydoux went onto explain what really happened in order. At the very beginning, anterior PARs stop posterior PARs from entering the membrane . When the sperm enters, it brings along a centrosome that bursts into microtubules and there was a correlation between that and the posterior PAR proteins at the membrane. Blocking of the microtubule formation of the sperm, stopped the PAR proteins from reaching the membrane. However, when the oocyte nucleus about to undergo meiotic division – the spindle formation allowed the PAR protein to access the membrane. This is suggested that it was not a question of sperm vs oocyte, it was more of a question of which cell made a rich microtubule first. In wild type, meiotic spindles are more transient, whereas the sperm asters are much more dense and stable.
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