Multiparameter flow cytometry has become a standard in diagnosis and prognosis of patients with plasma cell disorders. New technology created a (NFG) or next-generation flow cytometry that measured characteristics of cells to detect minimal residual disease (MRD) in a cost effective way. This method could also be used to detect circulating tumor cells and recent cases has shown its success in detecting multiple myelomas. Paraproteins are a type of protein detected in the bone marrow and other tissues when cancer or other diseases are present. Specifically, when plasma cells begin to make an abnormal protein (monoclonal) this is a sign of myeloma.
Jelinek, T, et al. “Current Applications of Multiparameter Flow Cytometry in Plasma Cell Disorders.” Nature News, Nature Publishing Group, 20 Oct. 2017, www.nature.com/articles/bcj201790.
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