T-cells play a key role as a part of the immune system. They identify pathogenic entities by recognition of non-self antigens on the damaged/infected/foreign cells (Neumann et al 2002). T-cells are able to destroy cells that possess an antigen that they are cable of binding to by three main pathways.(neumann et al. 2002). The first method of lysis for cytotoxic T-cells in the release of cytotoxic granules such as perforin, which break down the target cell's membrane causing death(Neumann et al. 2002). The second is by the activation of the RAS receptor pathway, T-cells can have the ligand for this receptor (CD95L) which activates the apoptosis pathway in the target cell (Cox and Der 2003). The third method that cytotoxic T-cells use to kill their target cells is the release of cytokines such as TNF-α, which can induce apoptotic pathways within the cell (Neumann et al 2002). Our T-cell will use a combination of these pathways to effectively kill tumor cells that present neoantigens that the T-cells bind to.
Cox AD and CJ Der. 2002. The dark side of Ras: regulation of apoptosis. Oncogene 22:
Neumann H, Medana IM, Bauer J, Lassmann H. 2003. Cytotoxic T lymphocytes in autoimmune
and degenerative CNS diseases. Trends in Neuroscience 25(6): 313-319.
2017 May 3.