Activating receptor tyrosine kinase
Upon receiving a signal, 2 receptor tyrosine kinases come together and dimerize, Dimerization allows the receptors to phosphorylate each other which means they add a phosphate to the opposing receptor and thus activates the kinase. The phosphorylated tyrosine creates binding sites for downstream protein effectors to bind. This binding area is called an SH2 domain. RTKS are active in survival signals where the cell need a constant signal telling it to continue to survive. They are also active in growth factor signaling pathways. These pathways can tell a cell to divide more quickly and proliferate cell growth or to limit cell growth.