In plants, there stem cells are located in the shoot meristem where WUSCHEL (WUS) homeobox genes and CLAVATA 3 (CLV3) genes are constantly being expressed through negative feedback loops. When plants want to grow, the shoot meristem WUS, a transcription factor, specifies stem cell identity for growth when it is expressed. WUS also turns on its own repressor CLV3 as well that in turn regulates shoot meristem size. This negative feedback loop is important in plant growth and regulation. CLV3 is a signal peptide that binds to CLV1 a receptor complex however the exact pathway for modifying CLV3 and its applicability for CLV signaling are unknown.