This Article discusses Noroviruses and how they are the number one cause of food-borne gastroenteritis and childhood diarrhea. Noroviruses are transmitted by contaminated food/water or through direct person to person contact. Noroviruses are single-stranded positive-sense RNA that are non-enveloped with an icosahedral shape. Not much was known about this viruses let alone what they targeted within the body, These scientist sought to find the targets of this norovirus in order to further understand and better treat this infection. What the researchers found was sure stunning. They had found that the major targets of these noroviruses were the Immune Cells that were heavily associated with gut-associated lymphoid tissue like macrophages, dendritic cells, B cells, and C cells. The lymphatic system is the bodies defense mechanism against harmful pathogen and lymphoid tissue are the cites in the body where the ever important lymph immune cells are produced..