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Antibiotic-resistant genes

Submitted by rhallice on Mon, 12/04/2017 - 12:34

Antibiotics play an important role in modern medicine as prophylactic treatment for cancer therapy and during surgeries. However the rise of resistance of bacteria to these antibiotics are causing problems posing a real danger in places like hospitals. Antibiotic resistance genes can spread in many different ways. One way is through plasmids that have these resistant genes encoded on them. However thanks to the hard work of scientist at the University of Montreal’s Department of Biochemistry and Molecular Medicine, a new approach to block this transfer of the resistant genes was developed. They screened a library of small chemical molecules for those that would bind to protein TraE, a component of the plasmid transfer machinery. Now that more information about the binding site is known, researchers can design more potent binding molecules that will in turn reduce the key transfer of resistant-antibiotic genes through the plasmids. One of the Scientist Christian Baron hopes that in the future with further research that this strategy can be used to discover more inhibitors of the transfer of resistant genes. University of Montreal researchers and chemists are now working on developing new molecules into powerful inhibitors of resistant gene transfer and hopefully these molecules can be applied in clinics in hospitals.