Biol. 580 DEVELOPMENTAL BIOLOGY 

 
MWF : 12:20                Morrill Room 349.                (3 credits)

Instructors :

Text: Developmental Biology - S.F.Gilbert Fourth Edition - Sinauer.
M.S.Kaulenas Section

Jan. 29 Organization.
Jan. 31
Feb. 19 		9 lectures.
Evolution and development; developmental patterns.
Primary issues and definitions.
Gene regulation - transcriptional mechanisms.
Axis specification - maternal effects.
Creating multicellularity - cleavage.
Feb. 21 EXAM I (25% of final grade).
Feb. 24-
Mar. 24 		9 lectures.
Gastrulation : regulatory genes (HOX genes and evolutionary considerations);
diffusable factors; CAMS and SAMS.
Mesoderm and endoderm : secondary inductions/terminal differentiation;
specific vertebrate examples: circulatory and haemopoetic systems;
muscle differentiation; pancreas; liver.
Mar. 26 EXAM II (25% of final grade).

J.Nambu Section

Mar. 28-
Apr. 16. 		9 lectures.
Specification and formation of neuroectoderm.
Neuroblast formation.
Determination of neuronal identity.
Patterning within the nervous system.
Axon pathfinding.
Neuronal cell death and trophic mechanisms.
Human developmental disorders.
Apr. 18 EXAM III (25% of final grade).

J.G.Kunkel Section

Apr. 23-
May 14 		10 lectures.
Gametogenesis - spermiogenesis and oogenesis.
Vitellogenesis - protein; ribosomal RNA; messenger RNA.
Pattern formation - segmentation; polar co-ordinate model.
Mammalian body axes.
Sex determination.
Role of development in the evolution of form.
During finals EXAM IV (25% of final grade).

Biol. 597C Discussion section for Bio 580 Developmental Biology.
Monday 1:10. Morrill 349 * * * Note: May 12 Discussion starts at 12:20

Feb. 3, 10 J.Kunkel Assignments of research topics - BCRC.
Feb. 10, 18, 24
Mar 7, 10, 24 		M.S.Kaulenas Discussions related to lecture topics.
Mar 31
Apr. 7, 14 		J.Nambu Discussions related to lecture topics.
Apr 23, 28, May 5 J.Kunkel Discussions related to lecture topics.
May 12 MSK, JK, JN Oral reports 12:20 to 14:00